A New Leukocyte Isoantigen System in Man

Abstract

The leukocyte antigens provide a rich new source of material for the study of genetic polymorphism in human populations. The inheritance of these antigens has been discussed previously by Dausset and Brecy (1957), Payne and Rolfs (1958), Lalezari and Spaet (1959), van Rood, van Leeuwen, and Eernisse (1959), Payne and Hackel (1961). The antigenic determinants identified by leukocyte agglutinins are distinct from those of the red blood cells, and have been detected in the granulocytes, lymphocytes, platelets and other tissues (van Rood 1962; Shulman, Marder, Aledort, and Hiller 1962a; Payne 1963).