Prenatal Diagnosis · 1997 · 19 citations · 8 references
MedicineMaternal HealthObstetricsMaternal-fetal MedicinePrenatal DiagnosisReproductive MedicineChorionic Villus SamplingPregnancy DiagnosisPrenatal Diagnosis Of HemoglobinopathiesPrenatal Genetic DiagnosisPrenatal Molecular TestingCarrier Screening In PregnancyCervical Mucus AnalysisFirst-trimester Prenatal DiagnosisPlacental Biopsy TechniqueTranscervical Chorionic Villus Sampling
Prenatal diagnoses were performed on six selected pairs of parents known to be carriers of Hb mutations by testing transcervical cells (TCCs) retrieved, prior to chorionic villus sampling (CVS), by aspiration of the cervical mucus from the pregnant mothers at 10-12 weeks of gestation. A concordance between the results of testing chorionic villus cells and isolated clumps of trophoblastic cellular elements was observed in four of the six cases.
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