An Efficient and Convenient Protocol for the Synthesis of Novel 12-Aryl- or 12-Alkyl-8,9,10,12-tetrahydrobenzo[<i>a</i>]xanthen-11-one Derivatives

Abstract

An efficient and direct procedure for the synthesis of novel 12-aryl- or 12-alkyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one derivatives has been described. The process employs a three-component condensation reaction in one-pot using 2-naphthol, aldehydes and cyclic 1,3-dicarbonyl compounds in the presence of a catalytic amount of NaHSO4·SiO2 in 1,2-dichloroethane under reflux.