Publication | Open Access

Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors

Medicinal ChemistryBiochemistryReductase InhibitorsNatural SciencesMedicineOrganic ChemistryX-ray Crystal StructureHeterocycle ChemistryPharmacologyPharmaceutical ChemistrySynthetic ChemistryDual Thymidylate SynthaseDrug Discovery