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Bilateral Gonadoblastoma Producing Steroid Hormones in a Patient with 45, X/46, XY Gonadal Dysgenesis

DOI

16

Citations

0

References

1990

Year

Y Fukamatsu, Yoshiharu Tsukahara, Seiichi Hayashi, Fumihiko Yoshikawa, Toru Fukuta
Gynecologic and Obstetric Investigation

Abstract

A case of bilateral gonadoblastoma in a phenotypic female with 45,X/46,XY gonadal dysgenesis is presented. Hormonal investigations revealed that serum testosterone, estradiol and beta-human chorionic gonadotropin decreased following excision of the tumors, but follicle-stimulating hormone and luteinizing homrone levels increased further. Immunohistochemical staining for testosterone and estradiol was positive in both Leydig and lutein-like cells in the tumor. It is suggested that gonadoblastoma is capable of producing testosterone and estradiol, and Leydig or lutein-like cells may be the actual source of these steroid hormones.