Noradrenaline induces phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of α1-adrenergic receptors

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

George Tokiwa, Sima Lev, Sara A. Courtneidge et al. · Nature · 1996 · 972 citations

Life Sciences, Biochemistry, Molecular Biology +14

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

Tim van Blesen, Brian E. Hawes, Deirdre K. Luttrell et al. · Nature · 1995 · 549 citations

Life Sciences, Biochemistry, Molecular Biology +14

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

Michel Faure, T. Voyno-Yasenetskaya, Henry R. Bourne · Journal of Biological Chemistry · 1994 · 481 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

Gregory J. Della Rocca, Tim van Biesen, Yehia Daaka et al. · Journal of Biological Chemistry · 1997 · 454 citations · Full text

Life Sciences, Cell Biology, Pharmacology +16

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.

Walter J. Koch, Brian E. Hawes, Lee F. Allen et al. · Proceedings of the National Academy of Sciences · 1994 · 421 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16