Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · 1999 · 61 citations · 17 references
DentistryDermatologyPharmacotherapyOral DiagnosisOral HistologyOral HistopathologyCorticosteroid TherapyMucocutaneous DisordersOral MucosaOral Mucosal DiseasesOral Mucosal LesionsTopical PreparationsDapsone TherapyImmunofluorescence StainingOral Cavity LesionsPemphigoid DiseasesRetrospective Case StudySteroid Combination TherapyTopical Steroid TherapyTreatment With Topical Corticosteroids
OBJECTIVE: The purpose of this retrospective study was to investigate the efficacy of dapsone therapy in the management of mucous membrane pemphigoid. STUDY DESIGN: The charts of 29 patients who had been diagnosed with mucous membrane pemphigoid by means of routine histologic analysis and direct immunofluorescence were reviewed. The oral features were graded according to severity of disease from 1 to 3. Each patient was assigned to one of 4 groups according to his or her response to therapy. RESULTS: Nine patients were treated successfully with topical corticosteroids alone. Eleven patients with moderate to severe disease who were treated initially with topical steroids showed minimal improvement; after dapsone was added, 7 of the 11 had total resolution of their lesions and 4 had greater than 75% improvement. Two patients had to discontinue dapsone because of side effects. CONCLUSIONS: In this group of 20 patients with moderate to severe mucous membrane pemphigoid, the use of dapsone in combination with topical corticosteroids caused greater than 75% resolution of oral lesions in all patients studied.
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Dapsone Suppresses Integrin-Mediated Neutrophil Adherence Function
Sally A Booth, Charles E. Moody, Mark V. Dahl et al. · Journal of Investigative Dermatology · 1992 · 172 citations
Francina Lozada‐Nur, C Miranda, R. Maliksi · Oral Surgery Oral Medicine Oral Pathology · 1994 · 144 citations