Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Dos D. Sarbassov, Siraj M. Ali, Shomit Sengupta et al. · Molecular Cell · 2006 · 2.6K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +6

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

Jonathan M. Shillingford, Noel Murcia, Claire H. Larson et al. · Proceedings of the National Academy of Sciences · 2006 · 798 citations · Full text

Medicine, Molecular Genetics, Nephrology +15

PKD1 interacts with PKD2 through a probable coiled-coil domain

Qian Feng, F. Joseph Germino, Yiqiang Cai et al. · Nature Genetics · 1997 · 661 citations

Life Sciences, Biochemistry, Molecular Biology +8

Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease

Guanqing Wu, Vivette D. D’Agati, Yiqiang Cai et al. · Cell · 1998 · 572 citations · Full text

Medicine, Genetics, Molecular Genetics +15

Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac Hypertrophy Induced by Pressure Overload

Julie R. McMullen, Megan C. Sherwood, Oleg Tarnavski et al. · Circulation · 2004 · 522 citations · Full text

Medicine, Cardiology, Pharmacology +15