T-cell recognition of muscle acetylcholine receptor subunits in generalized and ocular myasthenia gravis

Abstract

CD4+ and Thl responses in MG involve the entire AChR molecule. This likely results from spreading of the CD4+ sensitization to increasingly larger parts of the AChR as the disease progresses. The differential recognition of AChR subunits in oMG might be related to the preferential involvement of extrinsic ocular muscles, which express AChR containing the gamma subunit.