Solubilities of Salicylic Acid in Pure Solvents and Binary Mixtures Containing Cosolvent

Abstract

The solubility of salicylic acid in water, methanol, ethanol, ethyl acetate, polyethylene glycol (PEG) 300, and 1,4-dioxane and in various binary solvent mixtures, methanol + water, ethanol + water, ethanol + ethyl acetate, PEG 300 + water, and 1,4-dioxane + water, were determined using high-performance liquid chromatography (HPLC). The experimental solubility data were correlated by two local composition models: modified Wilson and nonrandom two-liquid (NRTL) 1.