Athymic Nude Rats Develop Severe Pulmonary Hypertension following Monocrotaline Administration

Abstract

Athymic nude rats developed severer PH than euthymic rats along with a greater number of mast cells and severer histopathological changes, such as thickening of the alveolar wall. Mast cell proliferation was considered to play a pivotal role in the development of PH in MCT-PH.