cAMP-responsive Element Modulator (CREM)α Protein Induces Interleukin 17A Expression and Mediates Epigenetic Alterations at the Interleukin-17A Gene Locus in Patients with Systemic Lupus Erythematosus

Abstract

Background: Expression levels of both IL-17A and transcription factor CREM are increased in T cells from SLE patients. Results: In primary human T cells, CREM binds to the proximal IL17A promoter and induces IL-17A expression by transcriptional activation and epigenetic modifications. Conclusion: CREM promotes IL-17A expression.