Use of Amitriptyline Cream in the Management of Entry Dyspareunia Due to Provoked Vestibulodynia

Abstract

Topical amitriptyline cream should be considered for first-line treatment in the management of patients with provoked vestibulodynia causing entry dyspareunia. The response rate is reasonable (56%), and it eliminates the problems with systemic administration, namely, drowsiness and the difficulty patients have in accepting antidepressant medication for their condition.