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Dual-action penems and carbapenems
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0
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1992
Year
Bioorganic ChemistryOrganic ChemistryNew SeriesAntimicrobial ChemotherapyHeterocycle ChemistryPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryCarbamate MoietyMode Of ActionMechanism Of ActionAntibacterial AgentAntimicrobial CompoundPharmacologyDual-action PenemsRepresentation TheoryNatural SciencesMicrobiologyDual-action Antibacterial AgentsMedicine
Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed for both classes of compounds, indicative of a dual-mode of action.