Journal of Medicinal Chemistry · 1992 · 38 citations · 0 references
MedicineChemistryMedicinal ChemistryAntimicrobial PharmacologyOrganic ChemistryStructure-activity RelationshipsAntibacterial AgentsAntibacterial PharmacologyMultidrug ResistanceAntibacterial Drug DevelopmentBroad-spectrum AntimicrobialsCarbapenem AntibioticsFluoroquinolone AntibioticsNovel Antibacterial Agents
Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed for both classes of compounds, indicative of a dual-mode of action.