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Stereoselective synthesis of 9-hydroxyellipticine glycosides, novel and highly active antitumor agents.
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1987
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Medicinal ChemistryBioorganic Chemistry9-Hydroxyellipticine GlycosidesBiochemistryGlycosylationNatural SciencesMedicineAnti-cancer AgentStereoselective SynthesisDrug DevelopmentActive Antitumor AgentsPharmacologyMethanolic AmmoniaPharmaceutical ChemistrySynthetic ChemistryDrug DiscoveryCadmium CarbonateNatural Product Synthesis
A series of novel and highly active antitumor agents, 9-hydroxyellipticine glycosides were stereoselectively synthesized in good yields by an improved condensation reaction between 9-acetoxyellipticine and peracylated glycosyl halides using cadmium carbonate, followed by the removal of acyl groups with methanolic ammonia.