Carbon Nanotube Based Sensor for Simultaneous Determination of Acetaminophen and Ascorbic Acid Exploiting Multiple Response Optimization and Measures in the Presence of Surfactant

Abstract

Abstract A simple procedure for the simultaneous determination of acetaminophen (AC) and ascorbic acid (AA) by differential pulse voltammetry (DPV) using a carbon nanotube paste electrode exploiting measures in cetylpyridinium bromide (CPB) medium is described. Under the best instrumental parameters of DPV, optimized by means of factorial design, the calibration plots in the range 100.0–700.0 µmol L −1 ( r =0.993) and 39.4–146.3 µmol L −1 ( r =0.995) with limits of detection of 7.1 and 2.1 µmol L −1 , were achieved for AA and AC, respectively. The developed method was successfully applied for the AC and AA determination in pharmaceutical formulations, whose accuracy was attested by comparison with HPLC method.