Fiber-type Caffeine Sensitivities in Skinned Muscle Fibers from Humans Susceptible to Malignant Hyperthermia

Abstract

The current study indicates that a truly MHS patient cannot have a false-negative result solely related to abnormal type II fibers contained in a given muscle strip. Although the occurrence of a very high proportion of type I fibers in MHN human muscle could result in a false-positive contracture outcome, such an occurrence is expected to be rare.