Japanese Circulation Journal · 1995 · 26 citations · 16 references
MedicineCardiologyPharmacologyCardiovascular PharmacotherapyClinical PharmacologyPharmacodynamicsCardiovascular DiseaseCardiovascular PharmacologyCholinergic PharmacologyCholinergic SignalingCoronary Artery DiseaseIschemic Heart DiseaseControl Group DesignCoronary HemodynamicsEicosapentaenoic AcidFish Oil SupplementationMatched Control GroupVariant Angina TreatmentVasomotionVasomotor Dysfunction
Impaired function of the endothelium may be a mechanism of the coronary vasospasm induced by acetylcholine. We examined whether purified eicosapentaenoic acid (EPA), a major component of fish oil, improves the coronary vasomotion in response to acetylcholine, and the effect of purified EPA on acetylcholine (ACh)-induced coronary vasospasm in 22 patients with variant angina. ACh was infused into the coronary artery both before and after 4 months of EPA treatment (EPA 1.8 g/day, n = 12). In the control group (n = 10) that did not receive EPA, the response of the coronary diameter to ACh did not change over time. In the EPA-treated group, the cholinergic response in non-spastic sites changed from vasoconstriction to vasodilation, while ACh-induced coronary vasospasm persisted at the spastic sites. Therefore, EPA treatment improved the coronary vasomotor responsiveness to ACh, but did not inhibit ACh-induced coronary vasospasm.
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Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.
Joseph A. Vita, Charles B. Treasure, E G Nabel et al. · Circulation · 1990 · 1.2K citations · Full text