JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin

Abstract

These data show that melittin and bee venom prevent LPS and SNP-induced NO and PGE2 production via JNK pathway dependent inactivation of NF-kappaB, and suggest that inactivation of JNK pathways may also contribute to the anti-inflammatory and anti-arthritis effects of melittin and bee venom.