Araguspongines K and L, New Bioactive Bis-1-oxaquinolizidine <i>N</i>-Oxide Alkaloids from Red Sea Specimens of <i>Xestospongia </i><i>e</i><i>xigua</i>

Abstract

In addition to the previously reported (+)-araguspongine A, (+)-araguspongine C, (+)-araguspongine D, (-)-araguspongine E, and (+)-xestospongin B, two new N-oxide araguspongines, (+)-araguspongine K and (+)-araguspongine L, are described here. Their structures were established on the basis of spectral analyses including (1)H-(15)N HMBC. The promising in vitro antimalarial and antituberculosis activities of araguspongine C are reported.