Concise copper-catalyzed one-pot tandem synthesis of benzimidazo[1,2-b]isoquinolin-11-one derivatives

Abstract

A simple and efficient copper-catalyzed one-pot tandem method has been developed for synthesis of benzimidazo[1,2-b]isoquinolin-11-one derivatives via reactions of substituted 2-halo-N-(2-halophenyl)benzamides with alkyl 2-cyanoacetates or malononitrile under mild conditions.