⁶⁸Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

Abstract

We have developed a (68)Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo.