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Synthesis of heterotelechelic poly(ethylene glycol)s and their characterization by MALDI-TOF-MS
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1999
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Synthetic MacromoleculeEthylene GlycolMacromolecular ChemistryEngineeringEnd Group ModificationPolymer ScienceSustainable PolymersChromatographyPolymer CharacterizationPeg DerivativesChemistryBiomolecular EngineeringPolymer ReactionPolymer ChemistryPolymer SynthesisPolymers
Two heterotelechelic poly(ethylene glycol)s were synthezised by end group modification of α-hydro-ω-hydroxy-poly(oxyethylene) (PEG). The first reaction route starts from heterobifunctional α-hydro-ω-octadecanoyloxy-poly(oxyethylene) (400) and comprises the synthesis of α-hydro-ω-carboxymethoxy-poly(oxyethylene). The second pathway starts from homotelechelic PEG(400) and leads to α-(2-propenyl)-ω-carboxymethylthio-poly(oxyethylene). Purification of the desired products was accomplished by means of ion exchange chromatography on DEAE Sephadex. PEG derivatives were characterized by means of NMR, IR, HPLC and GPC. MALDI-TOF-MS recorded in the reflectron mode served as a fine method that provides information on chemical composition as well as molecular weight.