Relapses After Treatment of External Genital Warts Are More Frequent in HIV-Positive Patients Than in HIV-Negative Controls

Abstract

In Brief Background Recurrences of cervical lesions associated with human papillomavirus are more frequent in HIV-infected (HIV+) than in HIV− women. Recurrences of external genital warts were investigated in HIV+ patients and HIV− control subjects. Goal To compare relapses after treatment of external genital warts between HIV+ and HIV− patients. Study Design At the sexually transmitted disease (STD) center in Brescia, Italy, 1336 patients (241 HIV+ and 1095 HIV−) with external genital warts were examined in the decade 1990 to 1999. Various local treatments were used. Results Treatments generally triggered recovery from the lesions. The relapses observed up to 1 year after the response, examined by survival analysis, were significantly (P < 0.001) more frequent in the HIV+ (160 cases; 66.4%) than in the HIV− (294 cases; 26.8%) subjects. Multiple relapses observed up to 1 year after treatment occurred in 69 of 241 HIV+ patients, as compared with 14 of 1095 HIV− control subjects (P < 0.001). Conclusion According to the study findings, HIV infection can be considered a risk factor for the development and recurrence of external genital warts. Multiple relapses should drive patients to HIV testing. Recurrences observed up to 1 year after treatments in 1336 patients with external genital warts were significantly (P < 0.001) more frequent in HIV+ patients (66.4%; 160/241) than in HIV– control subjects (26.8%; 294/1095).