Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid

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Genome Instability, Novel Gene, Genetic Disorder +10

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

Manish A. Shah, Nicole A. Datson, Lakshmi Srinidhi et al. · Cell · 1993 · 3.1K citations

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Neuropathological Classification of Huntingtonʼs Disease

Jean‐Paul Vonsattel, Richard H. Myers, Thomas J. Stevens et al. · Journal of Neuropathology & Experimental Neurology · 1985 · 2.6K citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

M. Flint Beal, Neil W. Kowall, David W. Ellison et al. · Nature · 1986 · 1.3K citations

Biochemistry, Natural Sciences, Quinolinic Acid +7

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

Joseph T. Coyle, Robert Schwarcz · Nature · 1976 · 1.2K citations

Neuroanatomy, Striatal Neurons, Neurology +8