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A new, high yield synthesis of 2-deoxy-2-fluoro-D-glucose
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1985
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High Yield SynthesisExperimental SynthesisBioorganic ChemistryEngineeringBiochemistryNatural SciencesFluorous SynthesisOrganic ChemistryCatalysisStereoselective SynthesisChemistrySynthesis MethodAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisTetraalkylammonium Fluorides
The reaction of 1,6-anhydro-3,4-di-O-benzyl-2-O-(trifluoromethanesulphonyl)-β-D-mannopyranose (4) with tetraalkylammonium fluorides provides a rapid, high yield synthetic route to 2-deoxy-2-fluoro-D-glucose.