Expression of Interleukin-1alpha, Interleukin-6, and Basic Fibroblast Growth Factor by Cultured Skin Substitutes before and after Grafting to Full-Thickness Wounds in Athymic Mice

Abstract

The sequence of cytokine synthesis in the wounds (i.e., rapid IL-1alpha increase followed by IL-6 expression) parallels serum levels reported after a septic challenge. These findings support the hypothesis that the wound is a source of systemic cytokines.