EVIDENCE FOR TWO SPECIES OF INSULIN-LIKE GROWTH FACTOR II (IGF II AND “BIG” IGF II) IN HUMAN SPINAL FLUID

Abstract

Human serum contains the somatomedins, insulin-like growth factor I and II (IGF I and II). In spinal fluid, however, only IGF II was found in measurable and significant amounts. In addition, an IGF II of larger mass could be detected by a radioimmunoassay for IGF II. This "big" IGF II is biologically active and has an apparent molecular weight of 9000.