Differences in the angiogenesis of benign and malignant ovarian tumors, demonstrated by analyses of color doppler ultrasound, immunohistochemistry, and microvessel density

Abstract

In this study, immunohistochemical analysis demonstrated that low resistance to blood flow in vessels within malignant ovarian tumors may be associated with a poorly developed muscular coat in the tumor vessels, compared with that observed in benign tumors. The difference in the angiogenic natures of benign and malignant ovarian tumors showing intratumoral blood flow may thus be correlated with the endothelial cell activity of the tumor vessels and not the MVD.