The Journal of Infectious Diseases · 1994 · 153 citations · 33 references
Veterinary MedicineImmunologyInfectious DiseasesClinical ImmunologyImmunology Of Infectious DiseasesImmunopathologyAnimal Infectious DiseasesImmunodeficiency DisordersImmunological Disease ModelsImmunopathology Of Infectious DiseasesVeterinary ImmunologyViral PathogenesisAnimal Viral PathogenesisCd8 Positive T Cell ResponsesCd8 Positive T CellsExperimental Animal Models Of Viral InfectionFeline Infectious DiseasesFeline VirusesRecurrent Respiratory InfectionsUpper Respiratory Infections
Cats naturally infected with feline immunodeficiency virus (FIV) develop an AIDS-like syndrome whereas experimentally infected cats do not. To investigate the role of cofactors in the development of this disease in cats, 7 specific pathogen-free (SPF) and 12 random-source (RS) cats were infected with FIV. Over 4 years, infected cats developed similar phenotypic and functional immune abnormalities characterized by early and chronic inversion of CD4+:CD8+ cell ratios and significantly decreased mitogen responses compared with controls. Beginning 18-24 months after infection, 10 RS cats developed chronic clinical disease typical of feline AIDS, including stomatitis and recurrent upper respiratory disease; 4 SPF cats also developed chronic clinical disease, 2 with neurologic disease and 2 with B cell lymphomas. Thus, immunologic background is important in the type of disease that develops in cats infected with FIV, and FIV represents a promising animal model for studying the immunopathogenesis of AIDS in humans.
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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
Angus Dalgleish, Peter C. L. Beverley, Paul R. Clapham et al. · Nature · 1984 · 3.5K citations