Enantioselective Aldol Reaction of <i>tert</i>‐Butyl Acetate using Titanium‐Carbohydrate Complexes

Abstract

The enantioselective transformation of many aldehydes to tert-butyl esters of 3-hydroxycarboxylic acids is possible with the titanium reagent 1 (R*, see preceding communication). Acetate enolates could not be directly used previously. Surprisingly, this aldol reaction is hardly temperature dependent, so that a high induction may also be achieved at room temperature. The reagents (CPTiC13 and R*OH) can be recovered.