Postnatal morphology and functional capacity of the kidney following prenatal treatment with dinoseb in rats

Abstract

Dinoseb has produced alterations that are suggestive of renal damage in mice and rats. Therefore it was of interest to determine the postnatal morphology and functional capacity of the kidney following prenatal treatment with dinoseb in rats. Fetal and neonatal rats treated with dinoseb on gestational d 10-12 had dilated renal pelves and ureters. Kidneys had dilated tubules and excessive mesenchymal tissue when examined perinatally. These pathological changes were reduced in incidence (kidney) or not detected (ureter) at 42 d postpartum and were not correlated with alterations in postnatal renal function. Livers from rats treated prenatally with dinoseb were vacuolated and necrotic even at 42 d postpartum. Rats treated prenatally with dinoseb had reduced body weights at 1 and 7 d postpartum. However, body weights of control and dinoseb-treated rats were not significantly different at 42 d of age. These results emphasize the need to determine the pesistence and functional consequences of anomalies detected in near-term fetuses for safety assessment of a chemical.