AKT/NF‐κB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies

Abstract

As endothelial cells and hematopoietic cells are mutually correlated in their development and growth, targeting both tumor cells and endothelial cells with agents possessing cytotoxic and antiangiogenic activities may lead to synergistic antitumor effects interrupting a reciprocal stimulatory loop between leukemia and endothelial cells.