Defining the normal cortisol response to the short Synacthen test: implications for the investigation of hypothalamic‐pituitary disorders

Abstract

The definition of the 'normal' response to Synacthen should be both gender and method related at all time points. The data suggest that up to one-third of untreated patients with pituitary disease may have subtle defects in the hypothalamic-pituitary-adrenal axis.