Unrestrained p38 MAPK Activation in <i>Dusp1/4</i> Double-Null Mice Induces Cardiomyopathy - Concepedia

Concepedia

Publication | Open Access

Unrestrained p38 MAPK Activation in <i>Dusp1/4</i> Double-Null Mice Induces Cardiomyopathy

DOI Full Paper Access

97

Citations

28

References

2012

Year

Mannix Auger‐Messier, Federica Accornero, Sanjeewa A. Goonasekera, Orlando F. Bueno, John N. Lorenz, Jop H. van Berlo, Robert N. Willette, Jeffery D. Molkentin

Circulation Research

Abstract

Our data demonstrate that Dusp1 and Dusp4 are cardioprotective genes that play a critical role in the heart by dampening p38 MAPK signaling that would otherwise reduce contractility and induce cardiomyopathy.

References

	Year	Citations

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