Palladium‐Catalyzed Enantioselective Domino Reaction for the Efficient Synthesis of Vitamin E

Abstract

A new route to vitamin E: The palladium-catalyzed enantioselective domino reaction of the unsaturated phenol derivative 1 with acrylate provides efficient access to the chiral chroman 2 with 96 % ee and in 84 % yield (see scheme). Intermediate 2 can then be converted into vitamin E in a few steps.