CHARACTERIZATION OF URINARY STEROIDS IN ADRENAL HYPERPLASIA: ISOLATION OF METABOLITES OF CORTISOL, COMPOUND S, AND DESOXYCORTICOSTERONE FROM A NORMOTENSIVE PATIENT WITH ADRENOGENITAL SYNDROME *

Abstract

Congenital virilizing adrenal hyperplasia miiay present a varied clinical picture. Patients have been described who have only excessive virilization (1); others have an associated Addison-like elec- trolyte disturbance (2, 3), with hypoglycemia (4), or with hypertension (5-9). Recent studies (10- 12) indicate that the manifestation of virilism may result from defects in the biosynthesis of cortisol.' The first suggestion regarding the nature of the