Synthesis of Maremycins A and D₁ via Cycloaddition of a Nitrone with (<i>E</i>)-3-Ethylidene-1-methylindolin-2-one

Abstract

A concise synthesis of maremycins A and D1 has been accomplished via cycloaddition of a chiral cyclic nitrone with ( E)-3-ethylidene-1-methylindolin-2-one as a key step. This synthesis clarifies the stereochemistry of the maremycins and is suitable for large-scale synthesis for biological screening.