Fungal Allergens Induce Cathelicidin LL-37 Expression in Chronic Rhinosinusitis Patients in a Nasal Explant Model

Abstract

LL-37 is significantly up-regulated at the mRNA and protein level in CRS patients in response to fungal allergens. However, EMCRS patients do not show increased LL-37 at either the mRNA or the protein level in response to Alternaria.