Journal of Comparative and Physiological Psychology · 1978 · 306 citations · 34 references
MedicinePharmacologyPhysiologyExperimental PharmacologyNeuropharmacologyPharmacodynamicsAutonomic Nervous SystemAutonomic Nervous System ResponsesAutonomic PharmacologyDehydration PhysiologyReceptor PharmacologyReceptor PhysiologyAngiotensin Receptor SignalingBeta-adrenergic AgentsCellular Dehydration ControlCellular Dehydration ResponseIntracellular DehydrationReceptorsThirst MechanismsThirst Regulation
The proposal of the subfornical organ (SFO) as a site of receptors for drinking induced by angiotensin II (AII) was investigated with several mutually confirmatory experiments. Intracranial injections of physiological doses of AII elicited drinking if and only if applied directly to the SFO (Experiment I). Ablation of the SFO selectively (Experiment 2) and permanently (Experiment 4) eliminated drinking elicited by physiological doses of intravenously infused AII. Animals in which SFO had been ablated responded normally to cellular dehydration but reduced responding to the extracellular thirsts of beta-adrenergic activation and hyperoncotic colloid dialysis (Experiment 3). Infusion of saralasin, an AII antagonist, directly into the SFO selectively and reversibly antagonized intravenous AII drinking (Experiment 5). The hypothesis that the SFO contains dipsogenic receptors for circulating AII is strongly supported.
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Subfornical Organ: Site of Drinking Elicitation by Angiotensin II
John B. Simpson, Aryeh Routtenberg · Science · 1973 · 421 citations