1c:I[419806,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/30036bedc5269936.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/cd5e572bc3e4eb92.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/d4ac9dcf27f6ff52.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 1d:T405,Although much experimental work has been done on endogenous uveitis, there have been relatively few successful animal experiments in which eye disease is produced without direct manipulation of the eye itself. Two recently reported techniques for producing uveitis experimentally show some promise of contributing to our understanding of disease of this type. Collins^1,2has described a uveitis, said to resemble sympathetic ophthalmia, in guinea pigs and monkeys sensitized with uveal tissue and the so-called "Freund adjuvants" (killed tubercle bacilli and mineral oil). Uveitis has also been reported to occur (Fog and Bardram³) in pigs with experimental allergic encephalomyelitis (EAE), an experimental demyelinative disease produced by giving animals inoculations of central nervous system antigen plus adjuvants.⁴In both these experiments, a number of lines of evidence suggest that an autoallergy is produced, in the first case with some component of uveal tissue as the antigen and in the1e:T412,In 1922, Verhoeff and Lemoine¹suggested that a certain type of postoperative intra-ocular inflammation following cataract extraction might be due to a reaction between retained lens substance and ocular tissues hypersensitive to lens substance. This suggestion was based on the fact that many of the persons with postoperative inflammation were sensitive to lens substance when tested by intracutaneous injections of lens extracts of human and animal origin. Normal persons tested with the same extracts did not react cutaneously. Verhoeff and Lemoine also found a characteristic histologic picture in the eyes removed after the development of the inflammation. In these eyes, the lenses were invaded by leukocytes and macrophages, and there were no demonstrable bacteria. For this type of intra-ocular inflammation they suggested the term, endophthalmitis phaco-anaphylactica. The foregoing hypothesis differs from that of Lagrange and Lacoste²and Straub³in that these writers postulate a primary toxicity of1f:T692,

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References