Catalytic C-F activation of polyfluorinated pyridines by nickel-mediated cross-coupling reactions.

Abstract

The cross-coupling reaction of pentafluoropyridine with tributyl(vinyl)tin affording 2-vinyltetrafluoropyridine by activation of a carbon-fluorine bond is catalysed by [NiF(2-C5NF4)(PEt3)2]; a similar reaction is observed with 2,3,5,6-tetrafluoropyridine.