Suppression of collagen‐induced arthritis through adenovirus‐mediated transfer of a modified tumor necrosis factor α receptor gene

Abstract

Systemic adenoviral-mediated transfer of the TNFI gene suppressed CIA during its transitory expression. Intraarticular gene transfer was limited by an adenoviral synovitis that was not overcome by delivery of the TNFI gene. TNFI is an excellent protein candidate for further therapeutic study.