Propranolol Inhibits Glucose Metabolism and ¹⁸F-FDG Uptake of Breast Cancer Through Posttranscriptional Downregulation of Hexokinase-2

Abstract

The expression of HK-2 was regulated by the activation of ADRB2 in 4T1 breast cancer cells primarily at the posttranscriptional level. Additionally, propranolol prevented glucose metabolism and (18)F-FDG PET imaging of 4T1 breast cancer tumors.