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Structure design of polysaccharides: novel concepts, selective syntheses, high value applications
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2001
Year
EngineeringBiomimetic MaterialsBiofabricationBio-based NanomaterialsPolysaccharideEnzyme ImmobilizationArtificial Blood VesselsHigh Value ApplicationsBiochemical EngineeringAmino DerivativesStructure DesignNanocelluloseNatural PolymerBiochemistrySelective SynthesesBiopolymersBiomolecular EngineeringBiomanufacturingBiotechnologySilyl GroupsHemicelluloseCarbohydrate-protein Interaction
Using protecting silyl groups, catalyzed transesterification, and stereochemically controlled SN2 mechanisms examples of well-defined 2-, 3-, 6-, and 2,6-ethers, esters, resp. amino derivatives of cellulose, starch, and related polysaccharides have been synthesized and characterized by two-dimensional NMR spectroscopy. Supramolecularly structured polymer matrices useful in biosensors could be developed by immobilization of enzymes like glucose oxidase and aromatic redox-chromogenic structures at 6-deoxy-6-(4-aminophenyl)-aminocellulose. Cellulose tubes “grown” biotechnologically from D-glucose in the culture medium of Acetobacter xylinum represent novel types of artificial blood vessels because of their unique highly-swollen nanofiber network-structure.