Comparison of Unit Resolution Srm And Tof-Ms At 12,000 Mass Resolution For Quantitative Bioanalysis of 11 Steroids From Human Plasma

Abstract

Although the results show wider linear range and slightly better sensitivity for most of the compounds with QqQ in comparison to TOF, acceptable performance was obtained for most of the compounds within the range of LOD to 2000 ng/ml (in plasma), this was also the case with LC-TOF-MS analysis. The main problem in TOF-MS analysis at 12,000 mass resolution from plasma was selectivity rather than sensitivity or linear range.