Concepedia

A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H

Satoshi Ohte, Masashi Shin, Hiroki Sasanuma, Katsumi Yoneyama, Masumi Akita, Kenji Ikebuchi, Eijiro Jimi, Yuichi Maruki, Masaru Matsuoka, Akira Namba,

Biochemical and Biophysical Research Communications · 2011 · 49 citations · 16 references

DOI

Concepts

References

16

Bone: Formation by Autoinduction

Marshall R. Urist · Science · 1965 · 5.6K citations

, , +17

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]

Takenobu Katagiri · The Journal of Cell Biology · 1994 · 1.5K citations · Full text

, , +16

A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

Eileen M. Shore, Meiqi Xu, George Feldman et al. · Nature Genetics · 2006 · 1.2K citations

, , +11

BMP type I receptor inhibition reduces heterotopic ossification

Paul B. Yu, Donna Y. Deng, Carol Lai et al. · Nature Medicine · 2008 · 628 citations · Full text

, , +12

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

Frederick S. Kaplan, Meiqi Xu, Petra Seemann et al. · Human Mutation · 2008 · 448 citations

, , +15