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A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H

FibrosisSclerostinBone Morphogenic ProteinTypical MutationPathologyOsteogenesisBenign CaseMatrix BiologyMedicineCell BiologyCell SignalingFibrodysplasia OssificansExtracellular MatrixConnective Tissue Disease