Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Marc S. Greenblatt, W P Bennett, Monica Hollstein et al. · PubMed · 1994 · 3.5K citations

Medicine, Genetics, Molecular Genetics +16

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

Marianne Frommer, Louise E. McDonald, David Millar et al. · Proceedings of the National Academy of Sciences · 1992 · 3.3K citations

Life Sciences, Genetics, Molecular Biology +14

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Steven J. Kuerbitz, Beverly Plunkett, William Walsh et al. · Proceedings of the National Academy of Sciences · 1992 · 1.9K citations

Medicine, Cell Biology, Oncology +15

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

James G. Herman, Adrian Merlo, Li Mao et al. · PubMed · 1995 · 1.4K citations

Medicine, Genetics, Oncology +17

Toxic effects of metals

Robert A. Goyer · 1991 · 1.1K citations

Pharmacy, Environmental Sciences, Toxicology +17