A Convenient Preparation of <i>N</i>-Alkyl and <i>N</i>-Arylamines by Smiles Rearrangement—Synthesis of Analogues of Diclofenac

Abstract

Abstract Smiles rearrangement of substituted aryloxyacetamides in which oxygen and nitrogen are separated by COCH2 group has been successful even when the aryloxy ring carries weak or no electron withdrawing group. Earlier reports of such reactions involved either strong electron withdrawing groups or a special catalyst. The diphenylamines thus obtained gave analogues of diclofenac in only one case.