Regional differences in the delayed rectifier current (IKr and IKs) contribute to the differences in action potential duration in basal left ventricular myocytes in guinea-pig

Abstract

There are significant transmural gradients in the electrophysiological properties of myocytes isolated from the base of the left ventricular free wall in guinea-pig. Sub-endocardial myocytes had a longer APD90 attributable in part to a significantly smaller IK density. We have been unable to identify M cells in the guinea-pig left ventricular free wall.